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PB-22 and 5F-PB-22 were being the 1st synthetic cannabinoids to incorporate a quinoline substructure and an ester linkage. These compounds are considered to are already synthesized Together with the intention of making a artificial cannabinoid prodrug, which might make improvements to absorption and confound detection. Ester bonds are simply biodegradable by spontaneous or endogenous, nonspecific esterase hydrolysis, which has been commonly Utilized in medicinal chemistry to produce ester prodrugs.
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